PRRX1-TOP2A interaction is a malignancy-promoting factor in human malignant peripheral nerve sheath tumours.

Shota TakihiraDaisuke YamadaTatsunori OsoneTomoka TakaoMasakiyo SakaguchiMichiyuki HakozakiTakuto ItanoEiji NakataTomohiro FujiwaraToshiyuki KunisadaToshifumi OzakiTakeshi Takarada

Published in: British journal of cancer (2024)

Targeting the PRRX1-TOP2A interaction in malignant tumours with high PRRX1 expression might provide a novel tumour-selective therapeutic strategy.

Keyphrases

peripheral nerve
endothelial cells
poor prognosis
induced pluripotent stem cells
pluripotent stem cells
cancer therapy
long non coding rna