Current insights in nutrition assessment and intervention for malnutrition or muscle loss in people with lung cancer: a narrative review.
Nicole K KissAnnie CurtisPublished in: Advances in nutrition (Bethesda, Md.) (2022)
Up to 70% of people with lung cancer may be affected by cancer-related malnutrition or muscle loss, depending on treatment modality and disease stage. This narrative review explores recent studies on malnutrition and muscle loss as well as nutritional and multimodal interventions to treat these conditions in the context of the changing treatment landscape in lung cancer. Various types of interventions including individualized counselling, protein and other specific nutrient supplementation, as well as multimodal interventions to treat malnutrition and muscle loss have been investigated. Overall, individualized dietary counselling, increasing protein intake and supplementation with omega-3 fatty acids appear to be beneficial for some, albeit varying, patient outcomes. Multimodal interventions, generally including a nutrition and exercise component, show promising results, however the impact on patient outcomes are mixed. A key finding of this review is a lack of large, randomised trials to guide nutrition intervention specifically in people with lung cancer. Despite the high prevalence of malnutrition and muscle loss in people with lung cancer and the known adverse outcomes, current evidence for nutrition intervention is limited. A targeted effort is required to improve the quality of evidence for nutrition intervention in this population to provide support for clinicians to deliver effective nutrition care.
Keyphrases
- physical activity
- randomized controlled trial
- skeletal muscle
- pain management
- clinical trial
- healthcare
- palliative care
- fatty acid
- body mass index
- study protocol
- amino acid
- hepatitis c virus
- cancer therapy
- drug delivery
- weight gain
- high intensity
- single cell
- human immunodeficiency virus
- protein protein
- atomic force microscopy
- hiv infected
- placebo controlled