Evolutionary adaptation highlights the interconnection of fatty acids, sunlight, inflammation and epithelial adhesion.
Leslea J HluskoMadeline G McNelisPublished in: Acta paediatrica (Oslo, Norway : 1992) (2022)
Gene variants that influence human biology today reflect thousands of years of evolution. Genetic effects on infant health are a major point of selective pressure, given that childhood survival is essential to evolutionary success. Knowledge of this evolutionary history can have implications for paediatric research. CONCLUSION: An episode of human adaptation to the extremely low ultraviolet radiation environment of the Arctic 20,000 years ago implicates the Ectodysplasin A Receptor (EDAR) and the Fatty Acid Desaturases (FADS) in human lactation and epithelial inflammation.
Keyphrases
- fatty acid
- endothelial cells
- genome wide
- healthcare
- induced pluripotent stem cells
- oxidative stress
- copy number
- pluripotent stem cells
- public health
- climate change
- dna methylation
- intensive care unit
- gene expression
- pseudomonas aeruginosa
- radiation therapy
- staphylococcus aureus
- transcription factor
- health information
- binding protein
- preterm infants
- preterm birth
- cell migration