The stay-at-home orders of the COVID-19 pandemic disrupted U.S. adolescents' lives in numerous ways during the spring of 2020, including substantial changes to in-person routines and increased reliance on digital media. For adolescent girls, stay-at-home practices may have implications for body image concerns. In this research brief, we examine adolescent girls' pandemic-related body image concerns and longitudinal associations with depressive symptoms. The sample included 93 U.S. adolescent girls ( M age = 15.01; 68.8% White), with approximately 2/3 at temperamental risk for depression. Participants self-reported their depressive symptoms and pandemic-related body image concerns via online surveys at three assessments: Time 1 occurred in April/May 2020, approximately one month into stay-at-home orders, followed by two-week and seven-month follow-up assessments. Two pandemic-related body image concerns were assessed: (1) concerns about disrupted appearance-management routines and (2) evaluating one's appearance on video-chat. Both forms of pandemic-related body image concerns predicted depressive symptoms two weeks later, and concerns about disrupted routines also predicted depressive symptoms seven months later. In an era of social distancing, frequent technology-based interactions, and disrupted routines, future work should continue to investigate adolescents' body image concerns and the implications for longer-term mental health outcomes.