Detection of O-Linked-N-Acetylglucosamine Modification and Its Associated Enzymes in Human Degenerated Intervertebral Discs.
Georgios NikolaouAristeidis Hristos ZibisApostolos H FyllosAntonios KatsioulisSotirios SotiriouAnastasios KotrotsiosMarkos SgantzosAikaterini VassiouDimitrios L ArvanitisPublished in: Asian spine journal (2017)
O-GlcNAc and OGA/OGT expression is shown to correlate for the first time with intervertebral disc cell degeneration. Increasing disc degeneration is associated with increasing O-GlcNAcylation in both nuclear and cytoplasmic proteins in human disc cells.