STAT3/miR-130b-3p/MBNL1 feedback loop regulated by mTORC1 signaling promotes angiogenesis and tumor growth.

Hongwu LiPing LiuDapeng LiZixi WangZhao DingMeng ZhouXu ChenManli MiaoJunli DingWei LinYehai LiuXiaojun Zha

Published in: Journal of experimental & clinical cancer research : CR (2022)

The STAT3/miR-130b-3p/MBNL1 feedback loop plays a vital role in mTORC1-mediated angiogenesis and tumor progression. This pathway could be targeted for therapeutic intervention of mTORC1-related cancers.

Keyphrases

endothelial cells
vascular endothelial growth factor
cell proliferation
randomized controlled trial
transcription factor
poor prognosis
wound healing
cancer therapy
young adults