Submacular integration of hESC-RPE monolayer xenografts in a surgical non-human primate model.
Zengping LiuTanja IlmarinenGavin S W TanHeidi HongistoEdmund Y M WongAndrew S H TsaiSami Al-NawaisehGraham E HolderXinyi SuVeluchamy Amutha BarathiHeli SkottmanBoris V StanzelPublished in: Stem cell research & therapy (2021)
These results suggest both structural and functional submacular integrations of hESC-RPE xenografts. It is anticipated that surgical technique refinement will further improve the engraftment of macular cell therapeutics with significant translational relevance to improve future clinical trials.