Adipose endothelial cells mastering adipose tissues metabolic fate.
Zhe-Zhen LiaoLi RanXiao-Yan QiYa-Di WangYuan-Yuan WangJing YangJiang-Hua LiuXin-Hua XiaoPublished in: Adipocyte (2022)
Dynamic communication within adipose tissue depends on highly vascularized structural characteristics to maintain systemic metabolic homoeostasis. Recently, it has been noted that adipose endothelial cells (AdECs) act as essential bridges for biological information transmission between adipose-resident cells. Hence, paracrine regulators that mediate crosstalk between AdECs and adipose stromal cells were summarized. We also highlight the importance of AdECs to maintain adipocytes metabolic homoeostasis by regulating insulin sensitivity, lipid turnover and plasticity. The differential regulation of AdECs in adipose plasticity often depends on vascular density and metabolic states. Although choosing pro-angiogenic or anti-angiogenic therapies for obesity is still a matter of debate in clinical settings, the growing numbers of drugs have been confirmed to play an anti-obesity effect by affecting vascularization. Pharmacologic angiogenesis intervention has great potential as therapeutic strategies for obesity.
Keyphrases
- insulin resistance
- adipose tissue
- endothelial cells
- high fat diet induced
- high fat diet
- metabolic syndrome
- skeletal muscle
- type diabetes
- weight loss
- randomized controlled trial
- weight gain
- gene expression
- high glucose
- cell proliferation
- cell death
- fatty acid
- patient safety
- bone mineral density
- body mass index
- cell cycle arrest
- pi k akt