Crystalline silica-induced pulmonary inflammation and autoimmunity in mature adult NZBW/f1 mice: age-related sensitivity and impact of omega-3 fatty acid intervention.
Lauren K HeineTasha ScarlettJames G WagnerRyan P LewandowskiAbby D BenninghoffAshleigh N TindleAnna E SkedelJack R HarkemaJames J PestkaPublished in: Inhalation toxicology (2024)
These results highlight life-stage significance in this preclinical lupus model and underscore omega-3 fatty acids' therapeutic potential against toxicant-triggered autoimmune responses.
Keyphrases
- fatty acid
- oxidative stress
- systemic lupus erythematosus
- randomized controlled trial
- diabetic rats
- drug induced
- high glucose
- pulmonary hypertension
- multiple sclerosis
- disease activity
- high fat diet induced
- room temperature
- rheumatoid arthritis
- type diabetes
- metabolic syndrome
- endothelial cells
- mesenchymal stem cells
- bone marrow
- insulin resistance
- adipose tissue