Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer.
Martin PichlerCristian Rodríguez-AguayoSu Youn NamMihnea Paul DragomirRecep BayraktarSimone AnfossiErik KnutsenCristina IvanEnrique Fuentes-MatteiSang Kil LeeHui LingTina Catela IvkovicGuoliang HuangLi HuangYoshinaga OkugawaHiroyuki KatayamaAyumu TaguchiEmine BayraktarRajat BhattacharyaPaola AmeroWilliam Ruixian HeAnh M TranPetra Vychytilova-FaltejskovaChristiane KlecDiana L BonillaXinna ZhangSanja KapitanovicBozo LoncarRoberta GafàZhihui WangVittorio CristiniSamir M HanashMenashe Bar-EliGiovanni LanzaOndrej SlabyAjay GoelIsidore RigoutsosGabriel Lopez-BeresteinGeorge Adrian CalinPublished in: Gut (2020)
Based on our findings, we discovered, FLANC as a novel primate-specific lncRNA that is highly upregulated in CRC cells and regulates metastases formation. Targeting primate-specific transcripts such as FLANC may represent a novel and low toxic therapeutic strategy for the treatment of patients.