Prediction of Brain Metastases Development in Patients With Lung Cancer by Explainable Artificial Intelligence From Electronic Health Records.

To the best of our knowledge, this is the first study to predict BM using structured EHR data. We achieved decent prediction performance for BM prediction and identified factors highly relevant to BM development. The sensitivity analysis demonstrated that both RETAIN and Kernel SHAP could discriminate unrelated features and put more weight on the features important to BM. Our study explored the potential of applying explainable artificial intelligence for future clinical applications.