MG53 Protects against Sepsis-Induced Myocardial Dysfunction by Upregulating Peroxisome Proliferator-Activated Receptor-α.

Xue HanDaili ChenNing LiufuFengtao JiQingshi ZengWeifeng Yao Minghui Cao

Published in: Oxidative medicine and cellular longevity (2020)

Both MG53 and PPARα were downregulated after sepsis shock. MG53 supplement protects the heart against SIMD by upregulating PPARα expression. Our results provide a new treatment strategy for SIMD.

Keyphrases

acute kidney injury
septic shock
intensive care unit
poor prognosis
insulin resistance
heart failure
high glucose
oxidative stress
binding protein
diabetic rats
fatty acid
atrial fibrillation
adipose tissue
combination therapy
endothelial cells
skeletal muscle