A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding.
Rami A Al-HoraniElsamani I AbdelfadielDaniel K AfosahShravan MorlaJyothi C SistlaBassem MohammedErika J MartinMasahiro SakagamiDonald F BrophyUmesh R DesaiPublished in: Journal of thrombosis and haemostasis : JTH (2019)
Overall, SCI is a highly promising, allosteric inhibitor of FXIa that induces potent anticoagulation in vivo. Further studies are necessary to assess SCI in animal models mimicking human clinical indications.