Umesh R Desai

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 33

Top Venues

Journal of medicinal chemistry

ACS chemical biology

Biomolecules

PLoS pathogens

Virginia Commonwealth University

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Virginia Commonwealth University

United States

Professor :: Medicinal Chemistry

Publications

Chelsea D Painter, Nehru Viji Sankaranarayanan, Balaji Nagarajan, Thomas Mandel Clausen, Alan M V West, Nicollette J Setiawan, Jeeyoung Park, Ryan N Porell, Phillip L Bartels, Daniel R Sandoval, Gabriel J Vasquez, John P Chute, Kamil Godula, Craig W Vander Kooi, Philip L S M Gordts, Kevin D Corbett, Christina M Termini, Umesh R Desai, Jeffrey D Esko
Alteration of Neuropilin-1 and Heparan Sulfate Interaction Impairs Murine B16 Tumor Growth. ACS chemical biology 19 (8) (2024)
Chelsea D Painter, Nehru Viji Sankaranarayanan, Balaji Nagarajan, Thomas Mandel Clausen, Alan M V West, Nicollette J Setiawan, Jeeyoung Park, Ryan N Porell, Phillip L Bartels, Daniel R Sandoval, Gabriel J Vasquez, John P Chute, Kamil Godula, Craig W Vander Kooi, Philip L S M Gordts, Kevin D Corbett, Christina M Termini, Umesh R Desai, Jeffrey D Esko
Alteration of Neuropilin-1 and Heparan Sulfate Interaction Impairs Murine B16 Tumor Growth. ACS chemical biology 19 (8) (2024)
Chelsea D Painter, Nehru Viji Sankaranarayanan, Balaji Nagarajan, Thomas Mandel Clausen, Alan M V West, Nicollette J Setiawan, Jeeyoung Park, Ryan N Porell, Phillip L Bartels, Daniel R Sandoval, Gabriel J Vasquez, John P Chute, Kamil Godula, Craig W Vander Kooi, Philip L S M Gordts, Kevin D Corbett, Christina M Termini, Umesh R Desai, Jeffrey D Esko
Alteration of Neuropilin-1 and Heparan Sulfate Interaction Impairs Murine B16 Tumor Growth. ACS chemical biology (2024)
Chelsea D Painter, Nehru Viji Sankaranarayanan, Balaji Nagarajan, Thomas Mandel Clausen, Alan M V West, Nicollette J Setiawan, Jeeyoung Park, Ryan N Porell, Phillip L Bartels, Daniel R Sandoval, Gabriel J Vasquez, John P Chute, Kamil Godula, Craig W Vander Kooi, Philip L S M Gordts, Kevin D Corbett, Christina M Termini, Umesh R Desai, Jeffrey D Esko
Alteration of Neuropilin-1 and Heparan Sulfate Interaction Impairs Murine B16 Tumor Growth. ACS chemical biology 19 (8) (2024)
Nagendraprabhu Ponnuraj, Haji Akbar, Justine V Arrington, Stephen J Spatz, Balaji Nagarajan, Umesh R Desai, Keith William Jarosinski
The alphaherpesvirus conserved pUS10 is important for natural infection and its expression is regulated by the conserved Herpesviridae protein kinase (CHPK). PLoS pathogens 19 (2) (2023)
Nehru Viji Sankaranarayanan, Srinivas Sistla, Balaji Nagarajan, John E Chittum, Joseph T Y Lau, Umesh R Desai
Computational studies on glycosaminoglycan recognition of Sialyl transferases. Glycobiology (2023)
Anjan K Pradhan, Jinkal Modi, Santanu Maji, Amit Kumar, Praveen Bhoopathi, Padmanabhan Mannangatti, Chunqing Guo, Daniel K Afosah, Mark C Mochel, Nitai D Mukhopadhyay, Joanne M Jeter, Xiang-Yang Wang, Umesh R Desai, Devanand Sarkar, Luni Emdad, Swadesh K Das, Paul B Fisher
Dual Targeting of the PDZ1 and PDZ2 Domains of MDA-9/Syntenin Inhibits Melanoma Metastasis. Molecular cancer therapeutics (2023)
Shravan Morla, Ongolu Ravikumar, Connor O'Hara, Rio Boothello, Alberto Vera, Elsamani I Abdelfadiel, Rawan Fayyad, Daniel K Afosah, Chetna Sharon, Leopoldo Fernandez, Syed Ammer Shah, Bhaumik B Patel, Umesh R Desai
Designing Synthetic, Sulfated Glycosaminoglycan Mimetics That Are Orally Bioavailable and Exhibiting In Vivo Anticancer Activity. Journal of medicinal chemistry 66 (2) (2023)
Samuel G Holmes, Umesh R Desai
Assessing Genetic Algorithm-Based Docking Protocols for Prediction of Heparin Oligosaccharide Binding Geometries onto Proteins. Biomolecules 13 (11) (2023)
Shravan Morla, Ongolu Ravikumar, Connor O'Hara, Rio Boothello, Alberto Vera, Elsamani I Abdelfadiel, Rawan Fayyad, Daniel K Afosah, Chetna Sharon, Leopoldo Fernandez, Syed Ammer Shah, Bhaumik B Patel, Umesh R Desai
Designing Synthetic, Sulfated Glycosaminoglycan Mimetics That Are Orally Bioavailable and Exhibiting In Vivo Anticancer Activity. Journal of medicinal chemistry 66 (2) (2023)
Daniel K Afosah, Rawan M Fayyad, Valerie R Puliafico, Spencer Merrell, Eltice K Langmia, Sophie R Diagne, Rami A Al-Horani, Umesh R Desai
Homogeneous, Synthetic, Non-Saccharide Glycosaminoglycan Mimetics as Potent Inhibitors of Human Cathepsin G. Biomolecules 13 (5) (2023)
Shravan Morla, Ongolu Ravikumar, Connor O'Hara, Rio Boothello, Alberto Vera, Elsamani I Abdelfadiel, Rawan Fayyad, Daniel K Afosah, Chetna Sharon, Leopoldo Fernandez, Syed Ammer Shah, Bhaumik B Patel, Umesh R Desai
Designing Synthetic, Sulfated Glycosaminoglycan Mimetics That Are Orally Bioavailable and Exhibiting In Vivo Anticancer Activity. Journal of medicinal chemistry 66 (2) (2023)
Nagendraprabhu Ponnuraj, Haji Akbar, Justine V Arrington, Stephen J Spatz, Balaji Nagarajan, Umesh R Desai, Keith William Jarosinski
The alphaherpesvirus conserved pUS10 is important for natural infection and its expression is regulated by the conserved Herpesviridae protein kinase (CHPK). PLoS pathogens 19 (2) (2023)
Elsamani I Abdelfadiel, Rama Gunta, Bharath Kumar Villuri, Daniel K Afosah, Nehru Viji Sankaranarayanan, Umesh R Desai
Designing Smaller, Synthetic, Functional Mimetics of Sulfated Glycosaminoglycans as Allosteric Modulators of Coagulation Factors. Journal of medicinal chemistry (2023)
Shravan Morla, Ongolu Ravikumar, Connor O'Hara, Rio Boothello, Alberto Vera, Elsamani I Abdelfadiel, Rawan Fayyad, Daniel K Afosah, Chetna Sharon, Leopoldo Fernandez, Syed Ammer Shah, Bhaumik B Patel, Umesh R Desai
Designing Synthetic, Sulfated Glycosaminoglycan Mimetics That Are Orally Bioavailable and Exhibiting In Vivo Anticancer Activity. Journal of medicinal chemistry (2023)
Shravan Morla, Ongolu Ravikumar, Connor O'Hara, Rio Boothello, Alberto Vera, Elsamani I Abdelfadiel, Rawan Fayyad, Daniel K Afosah, Chetna Sharon, Leopoldo Fernandez, Syed Ammer Shah, Bhaumik B Patel, Umesh R Desai
Designing Synthetic, Sulfated Glycosaminoglycan Mimetics That Are Orally Bioavailable and Exhibiting In Vivo Anticancer Activity. Journal of medicinal chemistry 66 (2) (2023)
Shravan Morla, Ongolu Ravikumar, Connor O'Hara, Rio Boothello, Alberto Vera, Elsamani I Abdelfadiel, Rawan Fayyad, Daniel K Afosah, Chetna Sharon, Leopoldo Fernandez, Syed Ammer Shah, Bhaumik B Patel, Umesh R Desai
Designing Synthetic, Sulfated Glycosaminoglycan Mimetics That Are Orally Bioavailable and Exhibiting In Vivo Anticancer Activity. Journal of medicinal chemistry 66 (2) (2023)
Shravan Morla, Ongolu Ravikumar, Connor O'Hara, Rio Boothello, Alberto Vera, Elsamani I Abdelfadiel, Rawan Fayyad, Daniel K Afosah, Chetna Sharon, Leopoldo Fernandez, Syed Ammer Shah, Bhaumik B Patel, Umesh R Desai
Designing Synthetic, Sulfated Glycosaminoglycan Mimetics That Are Orally Bioavailable and Exhibiting In Vivo Anticancer Activity. Journal of medicinal chemistry 66 (2) (2023)
Nagendraprabhu Ponnuraj, Haji Akbar, Justine V Arrington, Stephen J Spatz, Balaji Nagarajan, Umesh R Desai, Keith William Jarosinski
The alphaherpesvirus conserved pUS10 is important for natural infection and its expression is regulated by the conserved Herpesviridae protein kinase (CHPK). PLoS pathogens 19 (2) (2023)
Rio S Boothello, Nehru Viji Sankaranarayanan, Jyothi C Sistla, Balaji Nagarajan, Chetna Sharon, John E Chittum, Rabiya Y Niyaz, Swarnali Roy, Aditi Nandi, Connor P O'Hara, Rahaman Navaz Gangji, Daniel K Afosah, Ravikumar Ongolu, Bhaumik B Patel, Umesh R Desai
Glycan Modulation of Insulin-like Growth Factor-1 Receptor. Angewandte Chemie (International ed. in English) 61 (49) (2022)
Balaji Nagarajan, Nehru Viji Sankaranarayanan, Umesh R Desai
In-Depth Molecular Dynamics Study of All Possible Chondroitin Sulfate Disaccharides Reveals Key Insight into Structural Heterogeneity and Dynamism. Biomolecules 12 (1) (2022)
Nehru Viji Sankaranarayanan, Balaji Nagarajan, Umesh R Desai
Combinatorial Virtual Library Screening Study of Transforming Growth Factor-β2-Chondroitin Sulfate System. International journal of molecular sciences 22 (14) (2021)
John E Chittum, Nehru Viji Sankaranarayanan, Connor P O'Hara, Umesh R Desai
On the Selectivity of Heparan Sulfate Recognition by SARS-CoV-2 Spike Glycoprotein. ACS medicinal chemistry letters 12 (11) (2021)
Vaibhav Tiwari, Ritesh Tandon, Nehru Viji Sankaranarayanan, Jacob C Beer, Ellen K Kohlmeir, Michelle Swanson-Mungerson, Umesh R Desai
Preferential recognition and antagonism of SARS-CoV-2 spike glycoprotein binding to 3- O -sulfated heparan sulfate. bioRxiv : the preprint server for biology (2020)
Shravan Morla, Umesh R Desai
Discovery of Sulfated Small Molecule Inhibitors of Matrix Metalloproteinase-8. Biomolecules 10 (8) (2020)
Shravan Morla, Nehru Viji Sankaranarayanan, Daniel K Afosah, Megh Kumar, Apparao B Kummarapurugu, Judith A Voynow, Umesh R Desai
On the Process of Discovering Leads That Target the Heparin-Binding Site of Neutrophil Elastase in the Sputum of Cystic Fibrosis Patients. Journal of medicinal chemistry 62 (11) (2019)
Rami A Al-Horani, Elsamani I Abdelfadiel, Daniel K Afosah, Shravan Morla, Jyothi C Sistla, Bassem Mohammed, Erika J Martin, Masahiro Sakagami, Donald F Brophy, Umesh R Desai
A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding. Journal of thrombosis and haemostasis : JTH 17 (12) (2019)
Prem Raj B Joseph, Kirti V Sawant, Junji Iwahara, Roberto P Garofalo, Umesh R Desai, Krishna Rajarathnam
Lysines and Arginines play non-redundant roles in mediating chemokine-glycosaminoglycan interactions. Scientific reports 8 (1) (2018)
Balaji Nagarajan, Nehru Viji Sankaranarayanan, Bhaumik B Patel, Umesh R Desai
A molecular dynamics-based algorithm for evaluating the glycosaminoglycan mimicking potential of synthetic, homogenous, sulfated small molecules. PloS one 12 (2) (2017)
Daniel K Afosah, Rami A Al-Horani, Nehru Viji Sankaranarayanan, Umesh R Desai
Potent, Selective, Allosteric Inhibition of Human Plasmin by Sulfated Non-Saccharide Glycosaminoglycan Mimetics. Journal of medicinal chemistry 60 (2) (2017)
Nehru Viji Sankaranarayanan, Tamara R Strebel, Rio S Boothello, Kevin Sheerin, Arjun Raghuraman, Florence Sallas, Philip D Mosier, Nicholas D Watermeyer, Stefan Oscarson, Umesh R Desai
A Hexasaccharide Containing Rare 2-O-Sulfate-Glucuronic Acid Residues Selectively Activates Heparin Cofactor II. Angewandte Chemie (International ed. in English) 56 (9) (2017)
Krishna Mohan Sepuru, Balaji Nagarajan, Umesh R Desai, Krishna Rajarathnam
Molecular Basis of Chemokine CXCL5-Glycosaminoglycan Interactions. The Journal of biological chemistry 291 (39) (2016)
Rami A Al-Horani, Rajesh Karuturi, Michael Lee, Daniel K Afosah, Umesh R Desai
Allosteric Inhibition of Factor XIIIa. Non-Saccharide Glycosaminoglycan Mimetics, but Not Glycosaminoglycans, Exhibit Promising Inhibition Profile. PloS one 11 (7) (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

Umesh R Desai