Efficient Correction of Oncogenic KRAS and TP53 Mutations through CRISPR Base Editing.
Shady SayedOlga A SidorovaAlexander HennigMartina AugsburgCatherine P Cortés VesgaMoustafa AbohawyaLukas Theo SchmittDuran SürünDaniel E StangeJovan MirceticFrank BuchholzPublished in: Cancer research (2022)
Repairing KRAS mutations with base editors can be used for providing a better understanding of RAS biology and may lay the foundation for improved treatments for KRAS-mutant cancers.