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Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues.

Franziska HoschekJulia NatanMaximilian WagnerKirupa SathasivamAlshaimaa AbdelmoezBjörn von EinemGillian P BatesG Bernhard LandwehrmeyerAndreas Neueder
Published in: Molecular medicine (Cambridge, Mass.) (2024)
Our results show that HTT1a expression occurs throughout a wide range of tissues and likely with all CAG lengths. Our data from peripheral sample sources demonstrate that HTT1a is indeed generated throughout the body in a CAG repeat-length-dependent manner. Therefore, the levels of HTT1a might be a sensitive marker of disease state and/or progression and should be monitored over time, especially in clinical trials targeting HTT expression.
Keyphrases
  • poor prognosis
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  • endothelial cells
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