Cell type-specific loops linked to RNA polymerase II elongation in human neural differentiation.

Thousands of loops are decommissioned and gained upon human iPSC differentiation to NPCs/neuronsGenes transitioning from initiated-to-elongated exhibit robust mRNA upregulation when connected in cell type-specific promoter-enhancer loopsGenes transitioning from repressed-to-initiated exhibit slight increases in mRNA levels independent of loop statusUpon short-term RNAPolII degradation, loops formed by elongated genes are more severely disrupted than those anchoring initiated genes.