Effects of Anthocyanins on Vascular Health.
Ioana M MozoșCorina FlangeaDaliborca C VladCristina GugCostin MozosDana Liana StoianConstantin T LucaJarosław O HorbańczukOlaf K HorbańczukAtanas Georgiev AtanasovPublished in: Biomolecules (2021)
Cardiovascular disorders are leading mortality causes worldwide, often with a latent evolution. Vascular health depends on endothelial function, arterial stiffness, and the presence of atherosclerotic plaques. Preventive medicine deserves special attention, focusing on modifiable cardiovascular risk factors, including diet. A diet rich in fruits and vegetables has well-known health benefits, especially due to its polyphenolic components. Anthocyanins, water-soluble flavonoid species, responsible for the red-blue color in plants and commonly found in berries, exert favorable effects on the endothelial function, oxidative stress, inhibit COX-1, and COX-2 enzymes, exert antiatherogenic, antihypertensive, antiglycation, antithrombotic, and anti-inflammatory activity, ameliorate dyslipidemia and arterial stiffness. The present review aims to give a current overview of the mechanisms involved in the vascular protective effect of anthocyanins from the human diet, considering epidemiological data, in vitro and in vivo preclinical research, clinical observational, retrospective, intervention and randomized studies, dietary and biomarker studies, and discussing preventive benefits of anthocyanins and future research directions.
Keyphrases
- cardiovascular risk factors
- public health
- healthcare
- blood pressure
- oxidative stress
- physical activity
- mental health
- weight loss
- water soluble
- health information
- randomized controlled trial
- human health
- working memory
- cross sectional
- cardiovascular disease
- double blind
- metabolic syndrome
- open label
- dna damage
- clinical trial
- stem cells
- atrial fibrillation
- mesenchymal stem cells
- type diabetes
- electronic health record
- risk assessment
- big data
- cardiovascular events
- artificial intelligence
- bone marrow
- diabetic rats
- induced apoptosis
- drinking water
- hypertensive patients
- endoplasmic reticulum stress
- health risk assessment