Compulsivity and impulsivity traits linked to attenuated developmental frontostriatal myelination trajectories.
Gabriel ZieglerTobias U HauserMichael MoutoussisEdward T BullmoreIan M GoodyerFonagy PPeter B Jonesnull nullUlman LindenbergerRaymond J DolanPublished in: Nature neuroscience (2019)
The transition from adolescence to adulthood is a period when ongoing brain development coincides with a substantially increased risk of psychiatric disorders. The developmental brain changes accounting for this emergent psychiatric symptomatology remain obscure. Capitalizing on a unique longitudinal dataset that includes in vivo myelin-sensitive magnetization transfer (MT) MRI scans, we show that this developmental period is characterized by brain-wide growth in MT trajectories within both gray matter and adjacent juxtacortical white matter. In this healthy population, the expression of common developmental traits, namely compulsivity and impulsivity, is tied to a reduced growth of these MT trajectories in frontostriatal regions. This reduction is most marked in dorsomedial and dorsolateral prefrontal regions for compulsivity and in lateral and medial prefrontal regions for impulsivity. These findings highlight that psychiatric traits of compulsivity and impulsivity are linked to regionally specific reductions in myelin-related growth in late adolescent brain development.
Keyphrases
- white matter
- depressive symptoms
- resting state
- multiple sclerosis
- functional connectivity
- mental health
- working memory
- obsessive compulsive disorder
- transcranial magnetic stimulation
- genome wide
- borderline personality disorder
- cerebral ischemia
- computed tomography
- magnetic resonance imaging
- poor prognosis
- young adults
- contrast enhanced
- minimally invasive
- magnetic resonance
- cross sectional
- high frequency
- transcranial direct current stimulation
- diffusion weighted imaging
- drug induced