Relationship between Sphk1/S1P and microRNAs in human cancers.
Saeideh Gholamzadeh KhoeiHamid SadeghiPouria SamadiRezvan NajafiMassoud SaidijamPublished in: Biotechnology and applied biochemistry (2020)
Sphingosine kinases type 1 (SphK1) is a key enzyme in the phosphorylation of sphingosine to sphingosine 1-phosphate (S1P). Different abnormalities in SphK1 functions may correspond with poor prognosis in various cancers. Additionally, upregulated SphK1/S1P could promote cancer cell proliferation, angiogenesis, mobility, invasion, and metastasis. MicroRNAs as conserved small noncoding RNAs play major roles in cancer initiation, progression, metastasis, etc. Their posttranscriptionally mechanisms could affect the development of cancer growth or tumorigenesis suppression. The growing number of studies has described that various microRNAs can be regulated by SphK1, and its expression level can also be regulated by microRNAs. In this review, the relationship of SphK1 and microRNA functions and their interaction in human malignancies have been discussed. Based on them novel treatment strategies can be introduced.
Keyphrases
- poor prognosis
- papillary thyroid
- endothelial cells
- long non coding rna
- cell proliferation
- squamous cell
- childhood cancer
- lymph node metastasis
- cell cycle
- transcription factor
- young adults
- induced pluripotent stem cells
- pluripotent stem cells
- squamous cell carcinoma
- signaling pathway
- vascular endothelial growth factor