PCSK9 Inhibitor with Statin Therapy for Intracranial Artery Stenosis （PISTIAS): Rationale and design of a multicenter randomized controlled trial.
Xinzhi HuZong-Mu-Yu ZhangCaiyan LiuMing-Li LiYiyang LiuAnqi ChengQiuyu YuHaoyao GuoYinxi ZouLi ZhouHebo WangBo SongYong YouJian XiaJingfen ZhangZhibing AiQin-Jian SunJu HanJing LIuBaoquan LuJunshan ZhouGuanzeng LiPeng-Fei WangXiangqing LiYi AnBo WuZhongrui YanYining WangWei-Hai XuPublished in: International journal of stroke : official journal of the International Stroke Society (2024)
This trial will explore whether more significant plaque regression is achievable with treatment after combining statins and PCSK9 inhibitors, providing information about important efficacy, mechanism, and safety data.Trial registration number: ChiCTR2300068868; https://www.chictr.org.cn/.
Keyphrases
- study protocol
- randomized controlled trial
- phase iii
- cardiovascular disease
- phase ii
- coronary artery disease
- low density lipoprotein
- clinical trial
- open label
- electronic health record
- cross sectional
- big data
- lymph node metastasis
- healthcare
- type diabetes
- combination therapy
- deep learning
- placebo controlled
- data analysis