Fascin in Gynecological Cancers: An Update of the Literature.
Hadeel KheraldineSemir VranicHamda Al-ThawadiAla-Eddin Al MoustafaPublished in: Cancers (2021)
Fascin is an actin-binding protein that is encoded by the FSCN1 gene (located on chromosome 7). It triggers membrane projections and stimulates cell motility in cancer cells. Fascin overexpression has been described in different types of human cancers in which its expression correlated with tumor growth, migration, invasion, and metastasis. Moreover, overexpression of fascin was found in oncovirus-infected cells, such as human papillomaviruses (HPVs) and Epstein-Barr virus (EBV), disrupting the cell-cell adhesion and enhancing cancer progression. Based on these findings, several studies reported fascin as a potential biomarker and a therapeutic target in various cancers. This review provides a brief overview of the FSCN1 role in various cancers with emphasis on gynecological malignancies. We also discuss fascin interactions with other genes and oncoviruses through which it might induce cancer development and progression.
Keyphrases
- epstein barr virus
- endothelial cells
- papillary thyroid
- binding protein
- diffuse large b cell lymphoma
- cell adhesion
- single cell
- childhood cancer
- genome wide
- cell therapy
- induced pluripotent stem cells
- induced apoptosis
- cell proliferation
- poor prognosis
- copy number
- cell migration
- transcription factor
- genome wide identification
- stem cells
- lymph node metastasis
- squamous cell carcinoma
- pluripotent stem cells
- young adults
- dna methylation
- cell cycle arrest
- biofilm formation
- gene expression
- cell death
- oxidative stress
- candida albicans
- genome wide analysis