Genomic Patterns of Malignant Peripheral Nerve Sheath Tumor (MPNST) Evolution Correlate with Clinical Outcome and Are Detectable in Cell-Free DNA.
Isidro Cortes-CirianoChristopher D SteeleKatherine PiculellAlyaa Al-IbraheemiVanessa EuloMarilyn M BuiAikaterini ChatzipliBrendan C DicksonDana C BorcherdingAndrew FeberAlon GalorJesse HartKevin B JonesJustin T JordanRaymond H KimDaniel LindsayColin MillerYoshihiro NishidaPaula Z ProszekJonathan SerranoR Taylor SundbyJeffrey J SzymanskiNicole J UllrichDavid H ViskochilXia WangMatija SnuderlPeter J ParkAdrienne M FlanaganAngela C HirbeNischalan PillayDavid T Millernull nullPublished in: Cancer discovery (2023)
MPNST is the most common cause of death and morbidity for individuals with NF1, a relatively common tumor predisposition syndrome. Our results suggest that somatic copy-number and methylation profiling of tumor or cfDNA could serve as a biomarker for early diagnosis and to stratify patients into prognostic and treatment-related subgroups. This article is highlighted in the In This Issue feature, p. 517.
Keyphrases
- copy number
- mitochondrial dna
- peripheral nerve
- genome wide
- end stage renal disease
- dna methylation
- newly diagnosed
- ejection fraction
- chronic kidney disease
- machine learning
- peritoneal dialysis
- oxidative stress
- prognostic factors
- deep learning
- cell proliferation
- single cell
- inflammatory response
- lps induced
- nuclear factor