Doxapram versus placebo in preterm newborns: a study protocol for an international double blinded multicentre randomized controlled trial (DOXA-trial).

Jarinda A PoppeRobert B FlintAnne SmitsSten P WillemsenKelly K StormDebbie H NuytemansWes OnlandMarten J PoleyWillem P de BoodeKatherine CarkeekVincent CassartLuc CornettePeter H DijkMarieke A C HemelsIsabelle HermansMatthias C HüttenDorottya KelenEllen H M de KortAndré A KroonJulie LefevereKatleen PlaskieBreanne StewartMichiel VoetenMirjam M van WeissenbruchOlivia WilliamsInge A ZonnenbergThierry Lacaze-MasmonteilArjan B Te PasIrwin K M ReissAnton H van KaamKarel AllegaertG Jeroen HuttenSinno H P Simons

Published in: Trials (2023)

ClinicalTrials.gov NCT04430790 and EUDRACT 2019-003666-41. Prospectively registered on respectively June and January 2020.

Keyphrases

study protocol
randomized controlled trial
low birth weight
gestational age
phase iii
double blind
clinical trial
placebo controlled
open label
preterm birth
preterm infants
pregnant women
phase ii
cord blood
systematic review
cross sectional