Transcriptomic analysis of pulmonary artery smooth muscle cells identifies new potential therapeutic targets for idiopathic pulmonary arterial hypertension.
Matthew W GorrKrishna SriramAbinaya MuthusamyPaul A InselPublished in: British journal of pharmacology (2020)
These data provide insights regarding the expression of current and experimental PAH drug targets, GPCRs and GPCR-related genes as potentially new therapeutic targets in PAH-PASMCs. Overall, the findings identify genes and pathways that may contribute to IPAH-PASMC function and suggest that ADGRG6/GPR126 is a novel therapeutic target for IPAH.
Keyphrases
- pulmonary arterial hypertension
- pulmonary artery
- pulmonary hypertension
- genome wide
- coronary artery
- poor prognosis
- polycyclic aromatic hydrocarbons
- electronic health record
- big data
- fatty acid
- binding protein
- genome wide identification
- gene expression
- long non coding rna
- bioinformatics analysis
- data analysis
- machine learning
- drug induced
- deep learning