Identification of Aurora Kinase A as a Biomarker for Prognosis in Obesity Patients with Early Breast Cancer.
Junhan JiangZihe GuoJunnan XuTao SunXinyu ZhengPublished in: OncoTargets and therapy (2020)
Our finding demonstrates here for the first time that high expression of Aurora A was notably correlated with early recurrence and poor overall survival in obesity patients with early breast cancer. The Aurora A-Cyclin B1 axis could be a potential promising therapeutic target for cancer intervention and therapy.
Keyphrases
- early breast cancer
- insulin resistance
- metabolic syndrome
- weight loss
- high fat diet induced
- type diabetes
- weight gain
- randomized controlled trial
- free survival
- papillary thyroid
- poor prognosis
- squamous cell
- cell cycle
- body mass index
- binding protein
- cell proliferation
- squamous cell carcinoma
- human health
- physical activity
- childhood cancer
- young adults
- risk assessment
- lymph node metastasis