DREAM: a database of experimentally supported protein-coding RNAs and drug associations in human cancer.
Shupeng LiLulu LiXiangqi MengPenggang SunYi LiuYuntang SongSijia ZhangChuanlu JiangJinquan CaiZheng ZhaoPublished in: Molecular cancer (2021)
The Drug Response Gene Expression Associated Map, also referred as "DREAM" ( http://bio-big-data.cn:8080/DREAM ), is a manually curated database of experimentally supported protein-coding RNAs and drugs associations in human cancers. The current version of the DREAM documents 3048 entries about scientific literatures supported drug sensitivity or drug intervention related protein-coding RNAs from PubMed database and 195 high-throughput microarray data about drug sensitivity or drug intervention related protein-coding RNAs data from GEO database. Each entry in DREAM database contains detailed information on protein-coding RNA, drug, cancer, and other information including title, PubMed ID, journal, publish time. The DREAM database also provides some data visualization and online analysis services such as volcano plot, GO/KEGG enrichment function analysis, and novel drug discovery analysis. We hope the DREAM database should serve as a valuable resource for clinical practice and basic research, which could help researchers better understand the effects of protein-coding RNAs on drug response in human cancers.
Keyphrases
- adverse drug
- big data
- gene expression
- endothelial cells
- electronic health record
- high throughput
- randomized controlled trial
- healthcare
- artificial intelligence
- machine learning
- emergency department
- drug induced
- squamous cell carcinoma
- dna methylation
- binding protein
- health information
- protein protein
- amino acid
- pluripotent stem cells
- squamous cell
- young adults
- mental health