Circulating Exosomal circRNA_0063476 Impairs Expression of Markers of Bone Growth Via the miR-518c-3p/DDX6 Axis in ISS.

Zhi DuJinghong YuanZhiwen WuQi ChenXijuan Liu Jingyu Jia

Published in: Endocrinology (2022)

The authors identified a novel pathogenesis in ISS that exosome-derived hsa_circ_0063476 retards the expression of markers of endochondral ossification and impairs longitudinal bone growth via miR-518c-3p/DDX6 axis, which may provide a unique therapeutic avenue for ISS.

Keyphrases

poor prognosis
long non coding rna
cell proliferation
bone mineral density
long noncoding rna
binding protein
bone loss
soft tissue
bone regeneration
cross sectional
body composition