Activation of the pattern recognition receptor NOD1 in periodontitis impairs the osteogenic capacity of human periodontal ligament stem cells via p38/MAPK signalling.
Yuying HeZuping WuSirui ChenJiahe WangLi ZhuJing XieChenchen ZhouShujuan Zou
Published in: Cell proliferation (2022)
Our study revealed the expression status of NOD1 in periodontitis. Its activation greatly decreased the osteogenic capacity of hPDLSCs which was mediated by the phosphorylation of p38 downstream signalling.