Methylene tetrahydrofolate reductase (MTHFR) and vascular endothelial growth factor (VEGF) polymorphisms in Brazilian patients with Hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC).

Sylene C R Carvalho Luydson Richardson da Silva Vasconcelos Leonardo Gomes da Fonseca Rodrigo Feliciano do Carmo Michele Tatiana Pereira Tomitão Dayse C B L Aroucha Leila M M B Pereira Jose Tadeu Stefano Ulysses Ribeiro Claudia Pinto Marques Souza de Oliveira Flair Jose Carrilho

Published in: Clinics (Sao Paulo, Brazil) (2021)

Our results suggest that these polymorphisms may increase the risk of rapid tumor progression in patients with HCV infection. This subgroup of patients with HCC and who present polymorphism is more likely to be diagnosed with multinodular disease and not be amenable to receiving curative treatments. These data must be validated in larger cohorts, and the screening intervals can be customized based on genetic history.

Keyphrases

hepatitis c virus
vascular endothelial growth factor
human immunodeficiency virus
endothelial cells
poor prognosis
electronic health record
genome wide
big data
rectal cancer
copy number
randomized controlled trial
gene expression
clinical trial
phase iii
artificial intelligence