Longitudinal MRI Detects Onset and Progression of Chronic Rhinosinusitis from Infancy to School Age in Cystic Fibrosis.
Lena WucherpfennigFelix WuennemannMonika EichingerNiclas SchmittAngelika SeitzIngo BaumannMirjam StahlSimon Y GraeberJaehi ChungJens-Peter SchenkAbdulsattar AlrajabHans-Ulrich KauczorMarcus Alexander MallOlaf SommerburgMark Oliver WielpützPublished in: Annals of the American Thoracic Society (2022)
Longitudinal paranasal sinus MRI detects an early onset and progression of severity of CRS from infancy to school age, and response to lumacaftor/ivacaftor therapy in children with CF. Our data support its role for comprehensive non-invasive monitoring of CRS in children with CF. Clinical trial registered with ClinicalTrials.gov (NCT02270476).
Keyphrases
- cystic fibrosis
- early onset
- pseudomonas aeruginosa
- clinical trial
- lung function
- young adults
- chronic rhinosinusitis
- magnetic resonance imaging
- late onset
- contrast enhanced
- cross sectional
- weight gain
- randomized controlled trial
- stem cells
- computed tomography
- electronic health record
- physical activity
- study protocol
- body mass index
- mesenchymal stem cells