Intraoperative use of phenylephrine versus ephedrine and postoperative delirium: A multicenter retrospective cohort study.

Haobo MaElena AhrensLuca J WachtendorfAiman SuleimanDenys ShayRicardo Munoz-AcunaTim M TartlerBijan TejaSoeren WagnerBalachundhar SubramaniamJames RheeMaximilian S Schaefer

Published in: Anesthesiology (2023)

The administration of phenylephrine compared to ephedrine during general anesthesia was associated with higher odds of developing postoperative delirium. Based on our data, clinical trials are warranted to determine whether favoring ephedrine over phenylephrine for treatment of intraoperative hypotension can reduce delirium after surgery.

Keyphrases

patients undergoing
cardiac surgery
hip fracture
clinical trial
acute kidney injury
big data
cross sectional
randomized controlled trial
machine learning
double blind
phase ii
artificial intelligence
data analysis
phase iii