Optimisation of Organ Preservation treatment strategies in patients with rectal cancer with a good clinical response after neoadjuvant (chemo)radiotherapy: Additional contact X-ray brachytherapy versus eXtending the observation period and local excision (OPAXX) - protocol for two multicentre, parallel, single-arm, phase II studies.
Barbara M GeubelsBaukelien van TriestFemke P PetersMonique MaasGeerard L BeetsCorrie A M MarijnenPetra A CustersHarm J T RuttenJaqueline C M TheuwsAn-Sofie E VerrijssenJeltsje S CnossenJacobus W A BurgerBrechtje A GrotenhuisPublished in: BMJ open (2023)
NCT05772923.
Keyphrases
- locally advanced
- rectal cancer
- phase ii
- clinical trial
- open label
- double blind
- radiation therapy
- squamous cell carcinoma
- study protocol
- randomized controlled trial
- placebo controlled
- phase iii
- high resolution
- case control
- high dose
- magnetic resonance imaging
- photodynamic therapy
- cross sectional
- lymph node
- low dose
- electron microscopy