DEX-2-TKA-DEXamethasone twice for pain treatment after Total Knee Arthroplasty: A protocol for a randomized, blinded, three-group multicentre clinical trial.

Kasper Smidt Gasbjerg Daniel Hägi-PedersenTroels H LunnJanus Christian Jakobsen Soeren OvergaardNiels A PedersenJens BaggerPeter LindholmStig BrorsonHenrik M SchrøderKasper Højgaard Thybo Ole Mathiesen

Published in: Acta anaesthesiologica Scandinavica (2019)

EudraCT: 2018-001099-39 (08/06-18); ClinicalTrials.gov: NCT03506789 (24/04-2019). Editorial Comment This is the protocol for the largest randomized clinical trial investigating the effect of one or two doses of dexamethasones on pain treatment after total knee arthroplasty. Due to the pragmatic and rigerous design this study will deliver results of high quality and external validity.

Keyphrases

clinical trial
pain management
study protocol
chronic pain
randomized controlled trial
editorial comment
neuropathic pain
total knee arthroplasty
low dose
high dose
open label
cross sectional