Neuroprotective effects of intranasal extracellular vesicles from human platelet concentrates supernatants in traumatic brain injury and Parkinson's disease models.

Liling Delila Ouada Nebie Nhi Thao Ngoc LeKelly TimmermanDeng-Yao LeeYu-Wen Wu Ming-Li Chou Luc Buee Szu-Yi Chou David Blum David Devos Thierry Burnouf

Published in: Journal of biomedical science (2024)

The potential of PEV-based therapies in neuroprotection opens new therapeutic avenues for neurodegenerative disorders. The study advocates for clinical trials to establish the efficacy of PEV-based biotherapies in neuroregenerative medicine.

Keyphrases

traumatic brain injury
clinical trial
endothelial cells
randomized controlled trial
induced pluripotent stem cells
cerebral ischemia
pluripotent stem cells
phase ii
blood brain barrier
severe traumatic brain injury
climate change
subarachnoid hemorrhage
open label
phase iii
double blind