Human-Specific Transcriptome of Ventral and Dorsal Midbrain Dopamine Neurons.
Jimena Monzón-SandovalIlaria PoggioliniTobias IlmerRichard Wade-MartinsCaleb WebberLaura ParkkinenPublished in: Annals of neurology (2020)
Our results highlight functional enrichments of vesicular trafficking, ion transport/homeostasis and oxidative stress genes showing higher expression in the resistant neurons of the SNpc dorsal tier. Furthermore, the comparison of gene expression variation in human and mouse SNpc populations strongly argues for the need of human-focused omics studies. ANN NEUROL 2020;87:853-868.
Keyphrases
- spinal cord
- endothelial cells
- gene expression
- oxidative stress
- induced pluripotent stem cells
- pluripotent stem cells
- poor prognosis
- neuropathic pain
- dna methylation
- single cell
- metabolic syndrome
- rna seq
- uric acid
- induced apoptosis
- signaling pathway
- endoplasmic reticulum stress
- deep brain stimulation
- clinical evaluation
- genetic diversity
- prefrontal cortex