Down-regulation of PBK inhibits proliferation of human endometrial stromal cells in thin endometrium.

Qi ZhuSimin YaoYishan DongDan LiuHuiyan WangPeipei JiangChenyan DaiHaining LvChenrui CaoZhenhua ZhouLimin WangWenjing GouXiwen ZhangGuangfeng ZhaoYa L Hu

Published in: Reproductive biology and endocrinology : RB&E (2022)

The endometrial transcriptome in late-proliferative phase showed suppressed cell proliferation in women with thin endometria and decreased expression of PBK in human endometrial stromal cells (HESCs), to which inflammation and reactive oxygen species contributed.

Keyphrases

endothelial cells
cell proliferation
reactive oxygen species
endometrial cancer
induced pluripotent stem cells
pluripotent stem cells
poor prognosis
gene expression
cell cycle
genome wide
dna methylation
binding protein
signaling pathway