Detection of a historic reservoir of bedaquiline/clofazimine resistance-associated variants in Mycobacterium tuberculosis.
Camus NimmoArturo Torres OrtizCedric C S TanJuanita PangMislav AcmanJames D MillardLeonardo MontagnaniAlison D GrantMax O'DonnellAlex PymOla Brønstad BrynildsrudVegard EldholmLouis GrandjeanXavier DidelotFrancois BallouxLucy van DorpPublished in: Genome medicine (2024)
The presence of a pre-existing reservoir of Mtb strains carrying bedaquiline RAVs prior to its clinical use augments the need for rapid drug susceptibility testing and individualised regimen selection to safeguard the use of bedaquiline in TB care and control.
Keyphrases
- mycobacterium tuberculosis
- drug resistant
- multidrug resistant
- loop mediated isothermal amplification
- pulmonary tuberculosis
- healthcare
- escherichia coli
- palliative care
- copy number
- water quality
- quality improvement
- gene expression
- real time pcr
- emergency department
- sensitive detection
- drug induced
- genome wide
- dna methylation
- affordable care act