Limitations of the Unified Multiple System Atrophy Rating Scale as outcome measure for clinical trials and a roadmap for improvement.
Jose Alberto PalmaPatricio Millar VernettiMiguel A PerezFlorian KrismerKlaus SeppiAlessandra FanciulliWolfgang SingerPhillip LowItalo BiaggioniLucy Norcliffe-KaufmannMaria Teresa PellecchiaMaria José MartíHan-Joon KimMarcelo MerelloIva StankovicWerner PoeweRebecca BetenskyGregor WenningHoracio KaufmannPublished in: Clinical autonomic research : official journal of the Clinical Autonomic Research Society (2021)
Because of the limitations of the UMSARS, developing and validating an improved COA is a priority. The time is right for academic MSA clinicians together with industry, professional societies, and patient advocacy groups to develop and validate a new COA.