Plasma and urinary F2-isoprostane markers of oxidative stress are increased in cats with early (stage 1) chronic kidney disease.

Martin GranickAllison S LeuinLauren A Trepanier

Published in: Journal of feline medicine and surgery (2020)

Oxidative stress is prominent in cats with stage 1 CKD. Plasma and urinary F2-IsoPs are not interchangeable biomarkers in cats with stage 2 CKD. Placebo-controlled studies are indicated to evaluate dietary or pharmacologic doses of omega-3 fatty acids on redox stress and progression of renal dysfunction in cats with stage 1 CKD.

Keyphrases

chronic kidney disease
oxidative stress
end stage renal disease
early stage
fatty acid
dna damage
ischemia reperfusion injury
placebo controlled
diabetic rats
induced apoptosis
clinical trial
double blind
randomized controlled trial
study protocol
radiation therapy
lymph node
neoadjuvant chemotherapy
phase ii study