A polygenic risk score improves risk stratification of coronary artery disease: a large-scale prospective Chinese cohort study.
Xiangfeng LuZhongying LiuQingmei CuiFangchao LiuJianxin LiXiaoge NiuChong ShenDongsheng HuKeyong HuangJichun ChenXiaolong XingYingxin ZhaoFanghong LuXiaoqing LiuJie CaoShufeng ChenHongXia MaLing YuXianping WuXigui WuYing LiHuan ZhangXingbo MoLiancheng ZhaoJianfeng HuangLaiyuan WangWanqing WenChristina E BaileyFumihiko TakeuchiWoon Puay KohE Shyong TaiChing-Yu ChengTien Yin WongXuling ChangMark Yan-Yee ChanWei GaoHong ZhengKexin ChenJing ChenJiang HeClara Sze Man TangKaren Siu-Ling LamHung Fat TseChloe Yu Yan CheungAtsushi TakahashiMichiaki KuboNorihiro KatoChikashi C TeraoYoichiro KamataniPak Chung ShamChew-Kiat HengZhibin HuYuqing Eugene ChenTangchun WuHongbing ShenCristen J WillerDongfeng GuPublished in: European heart journal (2022)
The PRS could stratify individuals into different trajectories of CAD risk, and further refine risk stratification for CAD within each clinical risk strata, demonstrating a great potential to identify high-risk individuals for targeted intervention in clinical utility.