Eicosapentaenoic Acid Inhibits KRAS Mutant Pancreatic Cancer Cell Growth by Suppressing Hepassocin Expression and STAT3 Phosphorylation.

Ching-Feng ChiuMing-I HsuHsiu-Yen YehJi Min ParkYu-Shiuan ShenTe-Hsuan TungJun-Jie HuangHung-Tsung WuShih-Yi Huang

Published in: Biomolecules (2021)

Results of this study indicate that HPS is highly expressed by KRAS-mutated PDAC cells, and HPS/FGL1 plays a crucial role in altering lipid metabolism and increasing cell growth in pancreatic cancer. EPA supplements could potentially inhibit or reduce ACC-1-involved lipogenesis and HPS/FGL1-mediated cell survival in KRAS-mutated pancreatic cancer cells.

Keyphrases

wild type
induced apoptosis
poor prognosis
cell cycle arrest
cell proliferation
type diabetes
fatty acid
signaling pathway
cell death
binding protein
protein kinase
insulin resistance