The potentiating effect of hTFPI in the presence of hCD47 reduces the cytotoxicity of human macrophages.

Sung Han JungJeong Ho HwangSang Eun KimKim Young KyuHyo Chang ParkHoon Taek Lee

Published in: Xenotransplantation (2017)

When hCD47 was expressed, the expression of hTFPI leaded to tyrosine phosphorylation of SIRP-α in activated THP-1 cells via hTSP-1 inhibition, and consequently, it might improve the effect of hCD47-SIRP-a signaling.

Keyphrases

induced apoptosis
endothelial cells
poor prognosis
cell cycle arrest
induced pluripotent stem cells
pluripotent stem cells
endoplasmic reticulum stress
oxidative stress
protein kinase
long non coding rna