Aberrant expansion of circulating CD4+ CXCR5+ CCR7lo PD1hi Tfh precursor cells in idiopathic inflammatory myopathy.
Lu ZhangWenli LiYing CaiXia LiuQing-Lin PengLin LiangPublished in: International journal of rheumatic diseases (2019)
The percentage of circulating CCR7lo PD-1hi subset among total CD4+ CXCR5+ T cells and intracellular IL-21 expression expanded and showed significant correlation with disease activity in IIM. The circulating follicular helper T cell precursor may be involved in the pathogenesis, especially muscle injury in IIM.
Keyphrases
- disease activity
- rheumatoid arthritis
- regulatory t cells
- systemic lupus erythematosus
- dendritic cells
- rheumatoid arthritis patients
- induced apoptosis
- ankylosing spondylitis
- poor prognosis
- juvenile idiopathic arthritis
- oxidative stress
- cell migration
- skeletal muscle
- late onset
- reactive oxygen species
- endoplasmic reticulum stress
- binding protein