Systematic review and co-ordinate based meta-analysis to summarize the utilization of functional brain imaging in conjunction with human models of peripheral and central sensitization.
Sophie ClarkeRichard RogersVishvarani WanigasekeraFrancesca FardoHossein PiaZahra NochiNicolas MacianVincent LerayNanna Brix FinnerupGisèle PickeringAndré MourauxAndrea TruiniRolf-Detlef TreedeLuis Garcia-LarreaIrene TraceyPublished in: European journal of pain (London, England) (2024)
Experimental pain models that provide a surrogate for features of pathological pain conditions in healthy humans and functional imaging techniques are both highly valuable research tools. This review shows that when used together, they provide a wealth of information about brain activity during pain states and analgesia. These tools are promising candidates to help bridge the gap between animal and human studies, to improve translatability and provide opportunities for identification of new targets for back-translation to animal studies.
Keyphrases
- systematic review
- chronic pain
- pain management
- meta analyses
- endothelial cells
- neuropathic pain
- case control
- high resolution
- induced pluripotent stem cells
- pluripotent stem cells
- healthcare
- randomized controlled trial
- resting state
- white matter
- mass spectrometry
- brain injury
- subarachnoid hemorrhage
- blood brain barrier
- cerebral ischemia
- functional connectivity
- ultrasound guided