Modulation of Indoleamine 2,3-Dioxygenase 1 During Inflammatory Bowel Disease Activity in Humans and Mice.

Elisa ProiettiRenske W M PauwelsAnnemarie C de VriesElena OrecchiniClaudia VolpiCiriana OrabonaMaikel P PeppelenboschGwenny M FuhlerGiada Mondanelli

Published in: International journal of tryptophan research : IJTR (2023)

This is the first study demonstrating immunomodulatory activity of IDO1 in a chronic mouse model of DSS-induced colitis. As its expression and catalytic activity correlate with the grade of mucosal inflammation and treatment response, IDO1 could represent a promising biomarker for disease severity and treatment monitoring in IBD.

Keyphrases

disease activity
rheumatoid arthritis
systemic lupus erythematosus
mouse model
oxidative stress
rheumatoid arthritis patients
ankylosing spondylitis
poor prognosis
juvenile idiopathic arthritis
ulcerative colitis
type diabetes
binding protein
skeletal muscle
insulin resistance
wild type