BACHD rats expressing full-length mutant huntingtin exhibit differences in social behavior compared to wild-type littermates.
Giuseppe ManfréArianna NovatiIlaria FacciniAndrea C RossettiKari BoschRaffaella MolteniMarco A RivaJohanneke E Van der HarstHoa Huu Phuc NguyenJudith R HombergPublished in: PloS one (2018)
Taken together, these results indicate deficits in several parameters representative of sociability. Altered BDNF expression in the ventral striatum may contribute to the deficits in sociability in 8 months old BACHD rats. These data support the validity of the BACHD rat model in mimicking features of certain social deficits that could be relevant to symptoms in patients.
Keyphrases
- wild type
- traumatic brain injury
- end stage renal disease
- healthcare
- mental health
- ejection fraction
- newly diagnosed
- poor prognosis
- chronic kidney disease
- prognostic factors
- electronic health record
- big data
- cross sectional
- patient reported outcomes
- artificial intelligence
- long non coding rna
- depressive symptoms
- binding protein