Mediation of Successful Reperfusion Effect through Infarct Growth and Cerebral Edema: A Pooled, Patient-level Analysis of EXTEND-IA Trials and SELECT Prospective Cohort.
Amrou SarrajDeep Kiritbhai PujaraLeonid ChurilovClark SittonFelix Chun Fai NgAmeer E HassanMichael G AbrahamSpiros L BlackburnGagan SharmaNawaf YassiTimothy KleinigDarshan ShahTeddy Y WuWondwossen G TekleRonald F BudzikWilliam J HicksNirav VoraRandall C EdgellDiogo HaussenSantiago Ortega-GutierrezGabor TothLaith MaaliMohammad Ammar AbdulrazzakFaisal Al-ShaibiTareq AlMaghrabiVignan YogendrakumarFaris ShakerOsman MirAshish AroraKelsey DuncanSophia SundararajanAmanda OpaskarYin HuAbhishek RayJeffrey SunshineNicholas BambakidisSheryl Martin-SchildM Shazam HussainRaul NogueiraAnthony FurlanCathy A SilaJames C GrottaMark ParsonsPeter J MitchellGeoffrey A DonnanStephen M DavisGregory W AlbersBruce C V Campbellnull nullPublished in: Annals of neurology (2022)
In this mediation analysis from a pooled, patient-level cohort, a significant proportion(~80%) of successful reperfusion effect on functional outcome was mediated through reduction in infarct growth and cerebral edema. Further studies are required to confirm our findings, detect additional mediators to explain successful reperfusion residual effect and identify novel therapeutic targets to further enhance reperfusion benefits. This article is protected by copyright. All rights reserved.