PPAR-γ-induced changes in visceral fat and adiponectin levels are associated with improvement of steatohepatitis in patients with NASH.

Francesco Rubino Silvia Sabatini Fabrizia Carli Melania Gaggini Fernando Bril Renata Belfort-DeAguiar Vincenzo Positano Diana BarbSushma KadiyalaStephen A Harrison Kenneth Cusi

Published in: Liver international : official journal of the International Association for the Study of the Liver (2021)

Reduction in VF and improved VF/SC-distribution, combined with an increase in ADPN, mediate the histological benefits of PPAR-γ action, highlighting the central role of fat metabolism and its distribution on steatohepatitis disease activity in patients with NASH.

Keyphrases

disease activity
insulin resistance
adipose tissue
rheumatoid arthritis
systemic lupus erythematosus
fatty acid
rheumatoid arthritis patients
ankylosing spondylitis
juvenile idiopathic arthritis
metabolic syndrome
skeletal muscle
type diabetes