Dual role of CXCL8 in maintaining the mesenchymal state of glioblastoma stem cells and M2-like tumor-associated macrophages.
Wei YuanQian ZhangDanling GuChenfei LuDeobrat DixitRyan N GimpleYisu GaoJiancheng GaoDaqi LiDanyan ShanLang HuLu LiYangqing LiShusheng CiHao YouLinping YanKexin ChenNingwei ZhaoChuanhai XuJianyun LanDong LiuJunxia ZhangZhumei ShiQiulian WuKailin YangLinjie ZhaoZhixin QiuDeguan LvWei GaoHui YangFan LinQiang-Hu WangJianghong ManChao-Jun LiWeiwei TaoSameer AgnihotriXu QianStephen C MackNu ZhangYongping YouJeremy N RichGuan SunXiuxing WangPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
CXCL8 plays critical roles in maintaining the mesenchymal state of GSCs and M2-like TAM polarization in GBM, highlighting an interplay between cell-autonomous and cell-extrinsic mechanisms. Targeting CXCL8 and its downstream effectors may effectively improve GBM treatment.